Subject

• Fibrin sealants & components
• Components of fibrin sealants
• Thrombin
• Aprotinin
• Mechanism of action
• Clinical safety of Beriplast® P Combi-Set
• Beriplast® P Combi-Set: integrated safety system
• Beriplast® P Combi-Set ISS: controls
• Beriplast® P Combi-Set: NAT/PCR used to test plasma donations
• Beriplast® P Combi-Set ISS: virus inactivation and elimination
• Validation of virus Inactivation/elimination
• Viral reduction in Beriplast® P Combi-Set production
• Beriplast® P Combi-Set log₁₀ viral reduction factors: human fibrinogen
• Aprotinin and transmissible spongiform encephalopathy (TSE) risk
• Beriplast® P Combi-Set: adverse reactions
• Estimated risks of adverse events in clinical practice
• Beriplast® P Combi-Set: conclusions
• Experimental models
• Fibrin sealants increase the tensile strength of ruptured membranes in vitro
• Fibrin sealants strengthen colonic anastomoses
• Fibrin sealants strengthen vascular anastomoses
• Fibrin sealant reduces suture hole bleeding in a pig vascular graft model
• Effective haemostasis with fibrin sealant in experimental liver injury
• Comparison of two commercially available fibrin sealants
• Less force needed to deliver low viscosity fibrin sealants through delivery devices
• Strength of adhesion is inversely related to treatment viscosity
• Delivery devices
• Pantajet® dual syringe in open surgery
• Application of fibrin sealant in minimal invasive surgery
• Application of fibrin sealant through double-lumen probe in endoscopy
• Double-lumen probe (no needle) for use in endoscopy
• Flexible catheter for spray delivery

• Fibrin sealants
• Fibrinogen
• Factor XIII
• Calcium chloride
• Beriplast® P Combi-Set safety & tolerability
• Safety of Beriplast® P Combi-Set
• Beriplast® P Combi-Set ISS: safety at the source
• Beriplast® P Combi-Set ISS: safety at the source
• Beriplast® P Combi-Set: window period reduction by PCR
• Beriplast® P Combi-Set: virus elimination and inactivation steps
• Beriplast® P Combi-Set: viruses used in validation studies
• Beriplast® P Combi-Set log₁₀ viral reduction factors: human thrombin
• Beriplast® P Combi-Set log₁₀ viral reduction factors: human factor XIII
• Beriplast® P Combi-Set ISS: final product testing
• Beriplast® P Combi-Set: drug surveillance
• Safety of Beriplast® P Combi-Set
• Preclinical uses of fibrin sealant
• Fibrin sealants enhance tensile strength of intraocular wounds
• Human plasma derived fibrin sealants produce strong wound closure
• Fibrin sealants strengthen watertight sutures
• Effect of fibrin sealant in a femoral artery injury model
• Effective haemostasis in experimental atrial rupture
• Viscosity and delivery of fibrin sealants
• Viscosity of fibrin sealants
• Fibrin sealant reduces rate of adhesion formation in a rat model
• Fibrin sealant inhibits pericardial adhesions after cardiac surgery in dogs
• Fibrin sealants
• Application of fibrin sealant through spray tip in open surgery
• Application of fibrin sealant in minimal invasive surgery
• Application of fibrin sealant through double-lumen probe in endoscopy
• Application of fibrin sealant with double-lumen cannulae in microsurgery
• Flexible catheter